Without ‘mass’ living organism cannot be imagined. Gravity is the building block of the universe that acts on ‘mass’ on all time basis. Self gravity in biological mass works (mostly in non-Newtonian state) under secluded condition, especially under buoyed up force of fluids. In the particle hierarchy (sub-atom, atom, molecule, compound, organelles, cells, tissue, organ, organ system, and organism), actions of self gravity get prominence with accumulation of bio-‘mass’ from the level of organelles or cell. Self-Gravity is the force that attempts to compress an object to a point at body’s center of gravity, apart from its interaction with external world as ‘mutual gravity’. Domain of basic forces like nuclear or electromagnet are generally charge based, hence time bound. These cannot be a substitute for invisible gravitational binding action of all time. Free fall acceleration due to self gravity (g-value of biomass) that generates independently in such secluded biomass to the tune of ‘nanometer’ per second square to pico or femto level over small distance is quite a significant force for biological micro world and can not be discarded as insignificant comparing g-value of earth, moon being in ‘meter’ per second square. Effectiveness of miniature gravity and its interaction with larger gravitating body from the view of classical, quantum or non-Newtonian state stands as logical existence including mimics in biological micro world with astronomical macro world in various common phenomena.